A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis.

ABSTRACT: Forming an embryo from a zygote poses an apparent conflict for epigenetic regulation. On the one hand, the de novo induction of cell fate identities requires the establishment and subsequent maintenance of epigenetic information to harness developmental gene expression. On the other hand, the embryo depends on cell proliferation, and every round of DNA replication dilutes preexisting histone modifications by incorporation of new unmodified histones into chromatin. Here, we investigated the possible relationship between the propagation of epigenetic information and the developmental cell proliferation during Xenopus embryogenesis. We systemically inhibited cell proliferation during the G1/S transition in gastrula embryos and followed their development until the tadpole stage. Comparing wild

SUBMITTER: Pokrovsky D 

PROVIDER: S-EPMC8535184 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature