Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds.

ABSTRACT: The growing number of immunocompromised patients begs for efficient therapy strategies against invasive fungal infections. As conventional antifungal treatment is increasingly hampered by resistance to commonly used antifungals, development of novel therapy regimens is required. On the other hand, numerous fungal species are industrially exploited as cell factories of enzymes and chemicals or as producers of medically relevant pharmaceuticals. Consequently, there is immense interest in tapping the almost inexhaustible fungal portfolio of natural products for potential medical and industrial applications. Both the pathogenicity and production of those small metabolites are significantly dependent on the acetylation status of distinct regulatory proteins. Thus, classical lysine deacetylases

SUBMITTER: Bauer I 

PROVIDER: S-EPMC8535771 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature