Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.

ABSTRACT: The development of the cerebral cortex relies on the controlled division of neural stem and progenitor cells. The requirement for precise spatiotemporal control of proliferation and cell fate places a high demand on the cell division machinery, and defective cell division can cause microcephaly and other brain malformations. Cell-extrinsic and -intrinsic factors govern the capacity of cortical progenitors to produce large numbers of neurons and glia within a short developmental time window. In particular, ion channels shape the intrinsic biophysical properties of precursor cells and neurons and control their membrane potential throughout the cell cycle. We found that hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel subunits are expressed in mouse, rat, and human neu

SUBMITTER: Schlusche AK 

PROVIDER: S-EPMC8536352 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature