Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex.

ABSTRACT: Decision-making and representations of arousal are intimately linked. Behavioral investigations have classically shown that either too little or too much bodily arousal is detrimental to decision-making, indicating that there is an inverted "U" relationship between bodily arousal and performance. How these processes interact at the level of single neurons as well as the neural circuits involved are unclear. Here we recorded neural activity from orbitofrontal cortex (OFC) and dorsal anterior cingulate cortex (dACC) of macaque monkeys while they made reward-guided decisions. Heart rate (HR) was also recorded and used as a proxy for bodily arousal. Recordings were made both before and after subjects received excitotoxic lesions of the bilateral amygdala. In intact monkeys, higher HR facilitat

SUBMITTER: Fujimoto A 

PROVIDER: S-EPMC8536360 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature