Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause.

ABSTRACT: Embryonic diapause in mammals leads to a reversible developmental arrest. While completely halted in many species, European roe deer (Capreolus capreolus) embryos display a continuous deceleration of proliferation. During a 4-mo period, the cell doubling time is 2 to 3 wk. During this period, the preimplantation blastocyst reaches a diameter of 4 mm, after which it resumes a fast developmental pace to subsequently implant. The mechanisms regulating this notable deceleration and reacceleration upon developmental resumption are unclear. We propose that amino acids of maternal origin drive the embryonic developmental pace. A pronounced change in the abundance of uterine fluid mTORC1-activating amino acids coincided with an increase in embryonic mTORC1 activity prior to the resumption of devel

SUBMITTER: van der Weijden VA 

PROVIDER: S-EPMC8536382 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature