Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19.

ABSTRACT: In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular, and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse and correlate with autoantibody production but do not hinder the formation of neutralizing antibodies. Although plasmablasts followed interleukin-4 (IL-4) and BAFF-driven developmental trajectories, were polyclonal, and not enriched in autoreactive B cells, we identified two memory populations (CD80⁺/ISG15⁺ and CD11c⁺/S

SUBMITTER: Schultheiß C 

PROVIDER: S-EPMC8536484 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature