Time-dependent blood eosinophilia count increases the risk of kidney allograft rejection.

ABSTRACT:

Background

Growing evidence suggest that type 2 immune effectors play a role in solid organ transplantation. The aim of this study was to evaluate the impact of blood count eosinophils (BCEo) on immunological outcomes in kidney transplant recipients with stable graft function after 3 months post-transplant.

Method

We performed cause-specific Cox model considering BCEo, the use of calcineurin inhibitors and systemic corticoids as time-dependent explicative variables on a prospective cohort of 1013 kidney transplant patients who experienced kidney allograft rejection and/or the appearance of de novo donor specific antibodies after excluding common causes of increased BCEo..

Findings

BCEo ≥ 0.3 G/L was associated with a 3-fold increased risk of rejection independent of i

SUBMITTER: Colas L 

PROVIDER: S-EPMC8536518 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature