Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness.

ABSTRACT: Non-functioning pituitary adenomas (NFPAs) are typical pituitary macroadenomas in adults associated with increased mortality and morbidity. Although pituitary adenomas are commonly considered slow-growing benign brain tumors, numerous of them possess an invasive nature. Such tumors destroy sella turcica and invade the adjacent tissues such as the cavernous sinus and sphenoid sinus. In these cases, the most critical obstacle for complete surgical removal is the high risk of damaging adjacent vital structures. Therefore, the development of novel therapeutic strategies for either early diagnosis through biomarkers or medical therapies to reduce the recurrence rate of NFPAs is imperative. Identification of gene interactions has paved the way for decoding complex molecular mechanisms, including

SUBMITTER: Khayer N 

PROVIDER: S-EPMC8536755 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature