Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure.

ABSTRACT:

Background & aims

To provide an adequate treatment strategy for chronic hepatitis B, it is essential to know which patients are expected to have a good prognosis and which patients do not require therapeutic intervention. Previously, we identified the substitution of isoleucine to leucine at amino acid 97 (I97L) in the hepatitis B core region as a key predictor among patients with stable hepatitis. In this study, we attempted to identify the point at which I97L affects the hepatitis B virus (HBV) life cycle and to elucidate the underlying mechanisms governing the stabilization of hepatitis.

Methods

To confirm the clinical features of I97L, we used a cohort of hepatitis B e antigen-negative patients with chronic hepatitis B infected with HBV-I97 wild-type (wt) or HBV-I97L. Th

SUBMITTER: Honda T 

PROVIDER: S-EPMC8536788 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature