Case series, chemotherapy-induced cardiomyopathy: mind the family history!

ABSTRACT:

Background

Cardiotoxicity presenting as cardiomyopathy is a common side effect in cancer treatment especially with anthracyclines. The role of genetic predisposition is still being investigated.

Case summary

Four unrelated patients with a familial burden for cardiac disease, who developed cardiomyopathy after anthracycline treatment are presented. Case 1 received chemotherapy for breast cancer and developed a dilated left ventricle just after treatment. Her father had died unexpectedly while being screened for heart transplant. Case 2 was known with a family history of sudden cardiac death prior to her breast cancer diagnosis. She received anthracycline-containing chemotherapy treatment twice in 5 years due to recurrence of breast cancer. During that period, two brothers dev

SUBMITTER: Moghadasi S 

PROVIDER: S-EPMC8536866 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature