The Transcriptomic Landscape of Molecular Effects after Sublethal Exposure to Dinotefuran on Apis mellifera.

ABSTRACT: The decreasing number of bees is a global ecological problem. With the advancement of agricultural modernisation, the large-scale use of neonicotinoid insecticides is one of the main factors leading to the decline of bees. The aim of the present study was to investigate the effect and the mechanisms underlying bees impaired by dinotefuran. Acute (48 h) oral toxicity tests showed that a 5% lethal concentration (LC₅) was 0.220 mg/L, and a 20% lethal concentration (LC₂₀) was 0.458 mg/L. The gene expression profile shows that when compared with the control group, the LC₅ group induced 206 significantly upregulated, differentially expressed genes (DEGs) and 363 significantly downregulated DEGs, while the LC₂₀ group induced 180 significantly upregulate

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8537135 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature