D-Peptide-Based Probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy.

ABSTRACT: Positron emission tomography (PET) imaging of the C-X-C chemokine receptor 4 (CXCR4) with [⁶⁸Ga]PentixaFor has intrinsic diagnostic value and is used to select patients for personalized CXCR4-targeted radionuclide therapy with its therapeutic radiopharmaceutical companion [¹⁷⁷Lu]PentixaTher. However, a CXCR4-targeting radiopharmaceutical labeled with fluorine-18 is still of high value due to its favorable characteristics over gallium-68. Furthermore, clinical results with [¹⁷⁷Lu]PentixaTher are promising, but there is still room for improvement regarding pharmacokinetics and dosimetry profile. Therefore, this study aimed to develop innovative CXCR4-targeting radiopharmaceuticals, both for diagnostic and therapeutic purposes, starting from a D-amino acid-bas

SUBMITTER: Luyten K 

PROVIDER: S-EPMC8537445 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature