Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research?

ABSTRACT: In order to prevent new pathogen outbreaks and avoid possible new global health threats, it is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents and test new vaccines using the best methods. In the last decade, organoids have provided a groundbreaking opportunity for modeling pathogen infections in human brains, including Zika virus (ZIKV) infection. ZIKV is a member of the Flavivirus genus, and it is recognized as an emerging infectious agent and a serious threat to global health. Organoids are 3D complex cellular models that offer an in-scale organ that is physiologically alike to the original one, useful for exploring the mechanisms behind pathogens infection; additionally, organoids integrate data generated in vitro with traditional tools and ofte

SUBMITTER: Marrazzo P 

PROVIDER: S-EPMC8537471 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature