Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates.

ABSTRACT: Nipah virus (NiV) and respiratory syncytial virus (RSV) possess two surface glycoproteins involved in cellular attachment and membrane fusion, both of which are potential targets for vaccines. The majority of vaccine development is focused on the attachment (G) protein of NiV, which is the immunodominant target. In contrast, the fusion (F) protein of RSV is the main target in vaccine development. Despite this, neutralising epitopes have been described in NiV F and RSV G, making them alternate targets for vaccine design. Through rational design, we have developed a vaccine strategy applicable to phylogenetically divergent NiV and RSV that comprises both the F and G proteins (FxG). In a mouse immunization model, we found that NiV FxG elicited an improved immune response capable of neutralisi

SUBMITTER: Isaacs A 

PROVIDER: S-EPMC8537613 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature