Pharmacokinetic Variability and Target Attainment of Fluconazole in Critically Ill Patients.

ABSTRACT: Background: Fluconazole is one of the oldest antifungal drugs. Previous studies have raised concerns considering variability in exposure and inadequate target attainment in critically ill patients. The current study aims to define variability and target attainment for fluconazole exposure in a large group of critically ill patients. Methods: In this pharmacokinetic study, daily plasma trough samples and, if possible, 24 h urine samples were collected to determine fluconazole concentration. A minimum target trough concentration of 10-15 mg/L was selected, corresponding to a free area under the concentration-time curve above the minimum inhibitory concentration (fAUC/MIC) of at least 100 for an MIC of 4 mg/L. Covariates that significantly influenced fluconazole exposure were identified. Resu

SUBMITTER: Van Daele R 

PROVIDER: S-EPMC8538061 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature