Telocytes and Lymphatics of the Human Colon.

ABSTRACT: Telocytes (TCs) are a peculiar morphological type of stromal cells. They project long and moniliform telopodes, visible on various bidimensional sections. Originally regarded as "interstitial Cajal-like cells", gastrointestinal TCs were CD34+. Further double-labelling studies found that colon TCs are negative for the expressions of the PDGFR-α and α-SMA. However, the TCs in colon were not distinguished specifically from endothelial cells (ECs), vascular or lymphatic. A combinational approach is important for accurate TC identification. Hence, we designed an immunohistochemical study of human colon to check whether ECs and CD34+ TCs express different markers. Immunohistochemistry was performed on archived paraffin-embedded samples of human colon (nine cases) for the following markers: CD31,

SUBMITTER: Zurzu M 

PROVIDER: S-EPMC8538068 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature