Genetic Analyses of Amphotericin B Susceptibility in Aspergillus fumigatus.

ABSTRACT: Aspergillus fumigatus is a ubiquitous saprophytic mold that can cause a range of clinical syndromes, from allergic reactions to invasive infections. Amphotericin B (AMB) is a polyene antifungal drug that has been used to treat a broad range of systemic mycoses since 1958, including as a primary treatment option against invasive aspergillosis in regions with high rates (≥10%) of environmental triazole resistance. However, cases of AMB-resistant A. fumigatus strains have been increasingly documented over the years, and high resistance rates were recently reported in Brazil and Canada. The objective of this study is to identify candidate mutations associated with AMB susceptibility using a genome-wide association analysis of natural strains, and to further investigate a subset o

SUBMITTER: Fan Y 

PROVIDER: S-EPMC8538161 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature