Characterization of the Eukaryotic Virome of Mice from Different Sources.

ABSTRACT: Accumulating studies show that the host microbiome influences the development or progression of many diseases. The eukaryotic virome, as a key component of the microbiome, plays an important role in host health and disease in humans and animals, including research animals designed to model human disease. To date, the majority of research on the microbiome has focused on bacterial populations, while less attention has been paid to the viral component. Members of the eukaryotic virome interact with the commensal bacterial microbiome through trans-kingdom interactions, and influence host immunity and disease phenotypes as a collective microbial ecosystem. As such, differences in the virome may affect the reproducibility of animal models, and supplementation of the virome may enhance the trans

SUBMITTER: Zhang C 

PROVIDER: S-EPMC8538372 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature