Effect of Age on Innate and Adaptive Immunity in Hospitalized COVID-19 Patients.

ABSTRACT: An effective but balanced cellular and inflammatory immune response may limit the severity of coronavirus disease (COVID-19), whereas uncontrolled inflammation leads to disease progression. Older age is associated with higher risk of COVID-19 and a worse outcome, but the underlying immunological mechanisms for this age-related difference are not clear. We investigated the impact of age on viral replication, inflammation, and innate and adaptive cellular immune responses in 205 hospitalized COVID-19 patients. During the early symptomatic phase of COVID-19, we found that patients above 65 years had significantly higher viral load, higher levels of proinflammatory markers, and inadequate mobilization and activation of monocytes, dendritic cells, natural killer cells, and CD8 T cells compared

SUBMITTER: Cham LB 

PROVIDER: S-EPMC8538457 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature