The Hypothermic Effect of Hydrogen Sulfide Is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice.

ABSTRACT: Hydrogen sulfide (H₂S) has been shown in previous studies to cause hypothermia and hypometabolism in mice, and its thermoregulatory effects were subsequently investigated. However, the molecular target through which H₂S triggers its effects on deep body temperature has remained unknown. We investigated the thermoregulatory response to fast-(Na₂S) and slow-releasing (GYY4137) H₂S donors in C57BL/6 mice, and then tested whether their effects depend on the transient receptor potential ankyrin-1 (TRPA1) channel in Trpa1 knockout (Trpa1^-/-) and wild-type (Trpa1^+/+) mice. Intracerebroventricular administration of Na₂S (0.5-1 mg/kg) caused hypothermia in C57BL/6 mice, which was mediated by cutaneous

SUBMITTER: Olah E 

PROVIDER: S-EPMC8538668 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature