BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease.

ABSTRACT: The efficacy of SARS-CoV-2 mRNA-based vaccines in preventing COVID-19 disease has been extensively demonstrated; however, it is of uttermost importance to acquire knowledge on the persistence of immune-protection both in terms of levels of neutralizing antibodies and specialized memory cells. This can provide important scientific basis for decisions on the need of additional vaccine doses and on when these should be administered thus resulting in an improvement in vaccination schedules. Here, we briefly report the changes in antibody levels and cellular immunity following BNT162b2 administration. We show an important fall in anti S1-Spike antibodies in BNT162b2 vaccinated subjects overtime, paralleled by a contextual consolidation of specific spike (S) T-cells, mainly of the CD8+ compartme

SUBMITTER: Rossi C 

PROVIDER: S-EPMC8538967 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature