Sustained-Release Microspheres of Rivoceranib for the Treatment of Subfoveal Choroidal Neovascularization.
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ABSTRACT:
SUBMITTER: Kim ES
PROVIDER: S-EPMC8538988 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
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Sustained-Release Microspheres of Rivoceranib for the Treatment of Subfoveal Choroidal Neovascularization.
Kim E Seul ES Lee Min Sang MS Jeong Hayoung H Lim Su Yeon SY Kim Doha D Kim Dahwun D Jung Jaeback J Lyu Siyan S Cho Hee Joo HJ Kim Dong Min DM Suh Wonhee W Jeong Ji Hoon JH
Pharmaceutics 20210924 10
The wet type of age-related macular degeneration (AMD) accompanies the subfoveal choroidal neovascularization (CNV) caused by the abnormal extension or remodeling of blood vessels to the macula and retinal pigment epithelium (RPE). Vascular endothelial growth factor (VEGF) is known to play a crucial role in the pathogenesis of the disease. In this study, we tried to repurpose an investigational anticancer drug, rivoceranib, which is a selective inhibitor of VEGF receptor-2 (VEGFR2), and evaluate ...[more]
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