Cannabis Dopaminergic Effects Induce Hallucinations in a Patient with Parkinson's Disease.

ABSTRACT: Cannabis products that contain the tetrahydrocannabinol (THC) cannabinoid are emerging as promising therapeutic agents for the treatment of medical conditions such as chronic pain. THC elicits psychoactive effects through modulation of dopaminergic neurons, thereby altering levels of dopamine in the brain. This case report highlights the complexity associated with medicinal cannabis and the health risks associated with its use. A 57-year-old male with Parkinson's disease was experiencing worsening tremors and vivid hallucinations despite therapy optimization attempts. It was discovered that the patient took cannabis for chronic back pain, and a pharmacogenomics (PGx) test indicated the presence of variants for the COMT and HTR2A genes. These variants could increase dopamine levels and pred

SUBMITTER: Pizzolato K 

PROVIDER: S-EPMC8539120 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature