Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate.

ABSTRACT: Alzheimer's disease (AD) is the most frequent cause of neurodegenerative dementia and affects nearly 50 million people worldwide. Early stage diagnosis of AD is challenging, and there is presently no effective treatment for AD. The specific genetic alterations and pathological mechanisms of the development and progression of dementia remain poorly understood. Therefore, identifying essential genes and molecular pathways that are associated with this disease's pathogenesis will help uncover potential treatments. In an attempt to achieve a more comprehensive understanding of the molecular pathogenesis of AD, we integrated the differentially expressed genes (DEGs) from six microarray datasets of AD patients and controls. We identified ATPase H+ transporting V1 subunit A (ATP6V1A), BCL2 intera

SUBMITTER: Wu ATH 

PROVIDER: S-EPMC8539161 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature