Pharmacometabolomics by NMR in Oncology: A Systematic Review.

ABSTRACT: Pharmacometabolomics (PMx) studies aim to predict individual differences in treatment response and in the development of adverse effects associated with specific drug treatments. Overall, these studies inform us about how individuals will respond to a drug treatment based on their metabolic profiles obtained before, during, or after the therapeutic intervention. In the era of precision medicine, metabolic profiles hold great potential to guide patient selection and stratification in clinical trials, with a focus on improving drug efficacy and safety. Metabolomics is closely related to the phenotype as alterations in metabolism reflect changes in the preceding cascade of genomics, transcriptomics, and proteomics changes, thus providing a significant advance over other omics approaches. Nucl

SUBMITTER: Gomez-Cebrian N 

PROVIDER: S-EPMC8539252 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature