Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review.

ABSTRACT: The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past two years. Despite the development and administration of multiple vaccines, the mutation of newer strains and challenges to universal immunity has shifted the focus to the lack of efficacious drugs for therapeutic intervention for the disease. As with SARS-CoV, MERS-CoV, and other non-respiratory viruses, flavonoids present themselves as a promising therapeutic intervention given their success in silico, in vitro, in vivo, and more recently, in clinical studies. This review focuses on data from in vitro studies analyzing the effects of flavonoids on various key SARS-CoV-2 targets and presents an analysis of the structure-act

SUBMITTER: Kaul R 

PROVIDER: S-EPMC8539743 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature