A Promiscuous Halogenase for the Derivatization of Flavonoids.

ABSTRACT: Halogenation often improves the bioactive properties of natural products and is used in pharmaceutical research for the generation of new potential drug leads. High regio- and stereospecificity, simple reaction conditions and straightforward downstream processing are the main advantages of halogenation using enzymatic biocatalysts compared to chemical synthetic approaches. The identification of new promiscuous halogenases for the modification of various natural products is of great interest in modern drug discovery. In this paper, we report the identification of a new promiscuous FAD-dependent halogenase, DklH, from Frankia alni ACN14a. The identified halogenase readily modifies various flavonoid compounds, including those with well-studied biological activities. This halogenase has

SUBMITTER: Kolling D 

PROVIDER: S-EPMC8539768 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature