Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers.

ABSTRACT: Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens worldwide and among the more than 200 identified HPV types, approximately 15 high risk (HR-HPV) types are oncogenic, being strongly associated with the development of cervical cancer, anogenital cancers and an increasing fraction of head and neck squamous cell carcinomas (HNSCC). HPV-associated cervix cancer accounts for 83% of HPV-attributable cancers, and more than two-thirds of those cases occur in developing countries. Despite the high frequency of HPV infections, in most cases, the virus is cleared by the host immune response and only a small proportion of infected individuals develop persistent infections that can result in malignant transformation, indicating that other elements, including biological, g

SUBMITTER: Espinoza H 

PROVIDER: S-EPMC8539927 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature