Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis.

ABSTRACT: Vitamin C is a water-soluble antioxidant vitamin. Oxidative stress and its markers, along with inflammatory markers, are high during critical illness. Due to conflicting results of the published literature regarding the efficacy of vitamin C in critically ill patients, and especially the concerns for nephrotoxicity raised by some case reports, this meta-analysis was carried out to appraise the evidence and affirmation regarding the role of vitamin C in critically ill patients. We searched the database thoroughly to collect relevant studies that assessed intravenous vitamin C use in critically ill patients published until 25 February 2021. We included randomized controlled trials and observational studies with 20 or more critically ill patients who have received intravenous ascorbic acid (v

SUBMITTER: Shrestha DB 

PROVIDER: S-EPMC8539952 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature