Phage Therapy Experience at the Eliava Phage Therapy Center: Three Cases of Bacterial Persistence.

ABSTRACT: In this retrospective descriptive study we focus on cases of three patients who underwent phage therapy procedures at Eliava Phage Therapy Center (EPTC) in Tbilisi, Georgia. Patients with chronic infectious diseases related to Pseudomonas aeruginosa (two patients, lower respiratory tract infection (LRTI)) and Klebsiella pneumoniae (one patient, urinary tract infection (UTI)) are among those very few EPTC patients whose pathogens persisted through phage therapy. By looking at bacterial strains and personalized phages used against them we tried to point towards possible adaptation strategies that are employed by these pathogens. Genome restriction-based Pulsed Field Gel Electrophoresis (PFGE) profiling of strains isolated before and after phage therapy hints towards two strategies of adaptat

SUBMITTER: Zaldastanishvili E 

PROVIDER: S-EPMC8540005 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature