Progestins as Anticancer Drugs and Chemosensitizers, New Targets and Applications.

ABSTRACT: Progesterone and its synthetic analogues, progestins, participate in the regulation of cell differentiation, proliferation and cell cycle progression. Progestins are usually applied for contraception, maintenance of pregnancy, and hormone replacement therapy. Recently, their effectiveness in the treatment of hormone-sensitive tumors was revealed. According to current data, the anticancer activity of progestins is mainly mediated by their cytotoxic and chemosensitizing influence on different cancer cells. In connection with the detection of previously unknown targets of the progestin action, which include the membrane-associated progesterone receptor (PR), non-specific transporters related to the multidrug resistance (MDR) and mitochondrial permeability transition pore (MPTP), and checkpoin

SUBMITTER: Fedotcheva TA 

PROVIDER: S-EPMC8540053 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature