Teladorsagia Circumcincta Galectin-Mucosal Interactome in Sheep.

ABSTRACT: Teladorsagia circumcincta is the most important gastrointestinal parasite in the livestock industry in temperate regions around the world, causing great economic losses. The infective third-stage larvae (L3) of Teladorsagia circumcincta secrete a large number of excretory-secretory (E/S) molecules, some of which are likely to play critical roles in modulating the host immune response. One of the most abundant E/S molecules is a protein termed Tci-gal-1, which has similarity to mammalian galectins. Galectins are a family of carbohydrate-binding molecules, with characteristic domain organisation and affinity for β-galactosids that mediate a variety of important cellular functions including inflammation and immune responses. To understand the role of Tci-gal-1 at the host-parasi

SUBMITTER: Hafidi NN 

PROVIDER: S-EPMC8540209 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature