RespiCell^TM: An Innovative Dissolution Apparatus for Inhaled Products.

ABSTRACT: To overcome some of the shortfalls of the types of dissolution testing currently used for pulmonary products, a new custom-built dissolution apparatus has been developed. For inhalation products, the main in vitro characterisation required by pharmacopoeias is the deposition of the active pharmaceutical ingredient in an impactor to estimate the dose delivered to the target site, i.e., the lung. Hence, the collection of the respirable dose (<5 µm) also appears to be an essential requirement for the study of the dissolution rate of particles, because it results as being a relevant parameter for the pharmacological action of the powder. In this sense, dissolution studies could become a complementary test to the routine testing of inhaled formulation delivered dose and aerodynamic performance,

SUBMITTER: Sonvico F 

PROVIDER: S-EPMC8540329 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature