Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer's Disease Treatment.

ABSTRACT:

Background and purpose

The activation of 5-HT₄ receptors with agonists has emerged as a valuable therapeutic strategy to treat Alzheimer's disease (AD) by enhancing the nonamyloidogenic pathway. Here, the potential therapeutic effects of tegaserod, an effective agent for irritable bowel syndrome, were assessed for AD treatment. To envisage its efficient repurposing, tegaserod-loaded nanoemulsions were developed and functionalized by a blood-brain barrier shuttle peptide.

Results

The butyrylcholinesterase inhibitory activity of tegaserod and its neuroprotective cellular effects were highlighted, confirming the interest of this pleiotropic drug for AD treatment. In regard to its drugability profile, and in order to limit its peripheral distribution after IV administ

SUBMITTER: Seguy L 

PROVIDER: S-EPMC8540544 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature