Actions of Camptothecin Derivatives on Larvae and Adults of the Arboviral Vector Aedes aegypti.

ABSTRACT: Mosquito-borne viruses including dengue, Zika, and Chikungunya viruses, and parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe, and emerging mosquito-borne pathogens have pandemic potential. However, the rapid spread of insecticide resistance threatens our ability to control mosquito vectors. Larvae of Aedes aegypti were screened with the Medicines for Malaria Venture Pandemic Response Box, an open-source compound library, using INVAPP, an invertebrate automated phenotyping platform suited to high-throughput chemical screening of larval motility. We identified rubitecan (a synthetic derivative of camptothecin) as a hit compound that reduced A. aegypti larval motility. Both rubitecan and camptothecin displayed concen

SUBMITTER: Partridge FA 

PROVIDER: S-EPMC8540655 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature