P2Y12 Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment.

ABSTRACT: Gliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals and immunomodulatory pathways, which increase the tumor's aggressiveness. In response to hypoxia and glioma therapy, the amounts of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) strongly increase in the extracellular space, and the purinergic signaling is triggered by nucleotides' interaction in P2 receptors. Several cell types are present in the tumor microenvironment and can facilitate tumor growth. In fact, tumor cells can activate platelets by the ADP-P2Y12 engagement, which plays an essential role in the cancer context, protecting tumors from the immune attack and providing molecules that contrib

SUBMITTER: Morrone FB 

PROVIDER: S-EPMC8540665 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature