Smartphone-Assisted Protein to Creatinine Ratio Determination on a Single Paper-Based Analytical Device.

ABSTRACT: Proteinuria is a condition in which an excessive amount of protein is excreted in urine. It is, among others, an indicator of kidney disease or risk of cardiovascular disease. Rapid and reliable diagnosis and monitoring of proteinuria is of great importance for both patients and their physicians. For that reason, a paper-based sensor for proteinuria diagnosis was designed, optimized, and validated utilizing smartphone-assisted signal acquisition. In the first step, a few commonly employed protein assays were optimized and compared in terms of analytical performance on paper matrix. The tetrabromophenol blue method was selected as the one providing a sufficiently low limit of detection (39 mg·L-1) on the one hand and appropriate long-term stability (up to 3 months) on the other hand. The op

SUBMITTER: Lewinska I 

PROVIDER: S-EPMC8540694 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature