Effects of Nanopillar Size and Spacing on Mechanical Perturbation and Bactericidal Killing Efficiency.

ABSTRACT: Nanopatterned surfaces administer antibacterial activity through contact-induced mechanical stresses and strains, which can be modulated by changing the nanopattern's radius, spacing and height. However, due to conflicting recommendations throughout the theoretical literature with poor agreement to reported experimental trends, it remains unclear whether these key dimensions-particularly radius and spacing-should be increased or decreased to maximize bactericidal efficiency. It is shown here that a potential failure of biophysical models lies in neglecting any out-of-plane effects of nanopattern contact. To highlight this, stresses induced by a nanopattern were studied via an analytical model based on minimization of strain and adhesion energy. The in-plane (areal) and out-of-plane (contac

SUBMITTER: Velic A 

PROVIDER: S-EPMC8540829 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature