Clinicopathological features and prognostic significance of C5aR in human solid tumors: a Meta-analysis.

ABSTRACT:

Background

C5aR has been extensively studied in recent years as an essential component of the complement system. However, the role of C5aR in tumors has not been sufficiently investigated and summarized. The aim of this meta-analysis was to investigate the prognostic value of C5aR in solid tumors as well as the correlation between C5aR and clinicopathological features.

Methods

Relevant study collection was performed in PubMed, Embase, Web of Science, BIOSIS Previews, Cochrane Library until July 10, 2021. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Sensitivity analyses were performed to assess the robustness of this study, while publication bias was tested by Begg's and Egger's tests.

Results

A total of 11 studies

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8540875 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature