Host-Pathogen Interactions of Chlamydia trachomatis in Porcine Oviduct Epithelial Cells.

ABSTRACT: Chlamydia trachomatis (Ct) causes the most prevalent bacterial sexually transmitted disease leading to ectopic pregnancy and infertility. Swine not only have many similarities to humans, but they are also susceptible to Ct. Despite these benefits and the ease of access to primary tissue from this food animal, in vitro research in swine has been underutilized. This study will provide basic understanding of the Ct host-pathogen interactions in porcine oviduct epithelial cells (pOECs)-the counterparts of human Fallopian tube epithelial cells. Using NanoString technology, flow cytometry, and confocal and transmission-electron microscopy, we studied the Ct developmental cycle in pOECs, the cellular immune response, and the expression and location of the tight junction protein claudin-4. We show

SUBMITTER: Amaral AF 

PROVIDER: S-EPMC8540921 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature