Effect of Serial Systemic and Intratumoral Injections of Oncolytic ZIKV^BR in Mice Bearing Embryonal CNS Tumors.

ABSTRACT: The Zika virus (ZIKV) has shown a promising oncolytic effect against embryonal CNS tumors. However, studies on the effect of different administration routes and the ideal viral load in preclinical models are highly relevant aiming for treatment safety and efficiency. Here, we investigated the effect and effectiveness of different routes of administration, and the number of ZIKV^BR injections on tumor tropism, destruction, and side effects. Furthermore, we designed an early-stage human brain organoid co-cultured with embryonal CNS tumors to analyze the ZIKV^BR oncolytic effect. We showed that in the mice bearing subcutaneous tumors, the ZIKV^BR systemically presented a tropism to the brain. When the tumor was located in the mice's brain, serial systemic injecti

SUBMITTER: Ferreira RO 

PROVIDER: S-EPMC8541080 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature