Contribution of Metabolomics to Multiple Sclerosis Diagnosis, Prognosis and Treatment.

ABSTRACT: Metabolomics-based technologies map in vivo biochemical changes that may be used as early indicators of pathological abnormalities prior to the development of clinical symptoms in neurological conditions. Metabolomics may also reveal biochemical pathways implicated in tissue dysfunction and damage and thus assist in the development of novel targeted therapeutics for neuroinflammation and neurodegeneration. Metabolomics holds promise as a non-invasive, high-throughput and cost-effective tool for early diagnosis, follow-up and monitoring of treatment response in multiple sclerosis (MS), in combination with clinical and imaging measures. In this review, we offer evidence in support of the potential of metabolomics as a biomarker and drug discovery tool in MS. We also use pathway analysis of m

SUBMITTER: Rispoli MG 

PROVIDER: S-EPMC8541167 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature