Fatty Acids and Frailty: A Mendelian Randomization Study.

ABSTRACT: Observational studies have suggested that fatty acids such as higher levels of n-3 polyunsaturated fatty acids (PUFAs) may prevent frailty. By using Mendelian randomization analysis, we examined the relationship between fatty acids and frailty. We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of saturated fatty acids (palmitic acid, stearic acid), mono-unsaturated fatty acids (MUFAs) (palmitoleic acid, oleic acid), n-6 PUFAs (linoleic acid, arachidonic acid), and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for frailty index (FI) in 356,432 individuals in the UK Biobank. Although there were no robust associations on the MUFAs or the PUFAs, genetically predict

SUBMITTER: Tomata Y 

PROVIDER: S-EPMC8541183 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature