A Novel Three-Polysaccharide Blend In Situ Gelling Powder for Wound Healing Applications.

ABSTRACT: In this paper, alginate/pectin and alginate/pectin/chitosan blend particles, in the form of an in situ forming hydrogel, intended for wound repair applications, have been successfully developed. Particles have been used to encapsulate doxycycline in order to control the delivery of the drug, enhance its antimicrobial properties, and the ability to inhibit host matrix metalloproteinases. The presence of chitosan in the particles strongly influenced their size, morphology, and fluid uptake properties, as well as drug encapsulation efficiency and release, due to both chemical interactions between the polymers in the blend and interactions with the drug demonstrated by FTIR studies. In vitro antimicrobial studies highlighted an increase in antibacterial activity related to the chitosan amount

SUBMITTER: Amante C 

PROVIDER: S-EPMC8541204 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature