The Prevalence and Serological Association of Hepatitis D Virus Genotypes in Taiwan.

ABSTRACT: Hepatitis Delta Virus (HDV) is an RNA virus that requires the presence of hepatitis B surface antigen (HBsAg) to propagate into hepatocytes, with Genotype I being more prevalent globally. However, the prevalence of HDV genotypes in Taiwan is unknown. Accordingly, a cohort including 24 chronic HBV patients who received nucleos(t)ides (NUCs) between January 2002 and July 2018 was used to determine HDV genotypes and genotype specific serological association in chronic HBV carriers. HDV-positive genotypes in 18/24 (75%) males and 6/24 (25%) females were identified among chronic HBV patients. Viremia was lower in HDV-IV patients than in patients affected with other HDV genotypes (1.34 log₁₀ copies/mL vs. 3.30 log₁₀ copies/mL; p = 0.009). A logistics regression analy

SUBMITTER: Joseph K 

PROVIDER: S-EPMC8541235 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature