Lipase Assisted (S)-Ketoprofen Resolution from Commercially Available Racemic Mixture.

ABSTRACT: Ketoprofen is a commercially available drug sold as a racemic mixture that belongs to the family of non-steroidal anti-inflammatory drugs known as profens. It has been demonstrated (in vitro) that (S)-ketoprofen is around 160 times more potent than its enantiomer (R)-ketoprofen, while accumulation of (R)-ketoprofen can cause serious side effects, such as dyspepsia, gastrointestinal ulceration/bleeding, pain, salt and fluid retention, and hypertension. In this work, four commercially available lipases were systematically assessed. Parameters such as conversion, enantiomeric excess, and enantioselectivity were considered. Among them, and by evaluating lipase load, temperature, solvent, and alcohol, Candida rugosa lipase exhibited the best results in terms of enant

SUBMITTER: Estrada-Valenzuela D 

PROVIDER: S-EPMC8541352 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature