Association of oral microbiota with lung cancer risk in a low-income population in the Southeastern USA.

ABSTRACT:

Purpose

Oral microbiome plays an important role in oral health and systemic diseases, including cancer. We aimed to prospectively investigate the association of oral microbiome with lung cancer risk.

Methods

We analyzed 156 incident lung cancer cases (73 European Americans and 83 African Americans) and 156 individually matched controls nested within the Southern Community Cohort Study. Oral microbiota were assessed using 16S rRNA gene sequencing in pre-diagnostic mouth rinse samples. Paired t test and the permutational multivariate analysis of variance test were used to evaluate lung cancer risk association with alpha diversity or beta diversity, respectively. Conditional logistic regression models were used to evaluate the association of individual bacterial abundance or pr

SUBMITTER: Shi J 

PROVIDER: S-EPMC8541916 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature