The impact of organic extracts of seasonal PM_2.5 on primary human lung epithelial cells and their chemical characterization.

ABSTRACT: Lung epithelial cells serve as the first line of defense against various inhaled pollutant particles. To investigate the adverse health effects of organic components of fine particulate matter (PM_2.5) collected in Seoul, South Korea, we selected 12 PM_2.5 samples from May 2016 to January 2017 and evaluated the effects of organic compounds of PM_2.5 on inflammation, cellular aging, and macroautophagy in human lung epithelial cells isolated directly from healthy donors. Organic extracts of PM_2.5 specifically induced neutrophilic chemokine and interleukin-8 expression via extracellular signal-regulated kinase activation. Moreover, PM_2.5 significantly increased the expression of aging markers (p16, p21, and p27) and activated macroautophagy.

SUBMITTER: Park J 

PROVIDER: S-EPMC8541986 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature