Statins to mitigate cardiotoxicity in cancer patients treated with anthracyclines and/or trastuzumab: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Cardiotoxicity affects 5-16% of cancer patients who receive anthracyclines and/or trastuzumab. Limited research has examined interventions to mitigate cardiotoxicity. We examined the role of statins in mitigating cardiotoxicity by performing a systematic review and meta-analysis of published studies.

Methods

A literature search was conducted using PubMed, Embase, Web of Science, ClinicalTrials.gov, and Cochrane Central. A random-effect model was used to assess summary relative risks (RR), weighted mean differences (WMD), and corresponding 95% confidence intervals. Testing for heterogeneity between the studies was performed using Cochran's Q test and the I² test.

Results

Two randomized controlled trials (RCTs) with a total of 117 patients and four ob

SUBMITTER: Obasi M 

PROVIDER: S-EPMC8541988 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature