Using multi-layer perceptron to identify origins of replication in eukaryotes via informative features.

ABSTRACT:

Background

The origin is the starting site of DNA replication, an extremely vital part of the informational inheritance between parents and children. More importantly, accurately identifying the origin of replication has great application value in the diagnosis and treatment of diseases related to genetic information errors, while the traditional biological experimental methods are time-consuming and laborious.

Results

We carried out research on the origin of replication in a variety of eukaryotes and proposed a unique prediction method for each species. Throughout the experiment, we collected data from 7 species, including Homo sapiens, Mus musculus, Drosophila melanogaster, Arabidopsis thaliana, Kluyveromyces lactis, Pichia pastoris and Schizosaccharomyces pombe. In additi

SUBMITTER: Fan Y 

PROVIDER: S-EPMC8542328 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature